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September 15, 2023

Importantly, tirzepatide may influence fat distribution, particularly by reducing visceral and cervical adiposity, which are closely associated with upper airway obstruction in OSAS

Additionally, signaling studies show that while GLP2 peptide mimics native GIP actions at the GIP receptor, it exhibits biased agonism at the GLP-1 receptor, favoring cyclic AMP (cAMP) generation over beta-arrestin recruitment

Before the meeting, FDA scientists released briefing documents that strongly advised against making these peptides available due to lack of evidence and safety concerns, meaning the advisory committee went against their own experts

Alpha-lipoic acid scavenges several free radicals and helps to regenerate other antioxidants including ascorbic acid, glutathione, and vitamin E